Shortcut Navigation:

Dr. Peter de Lijser

Research Interests

Research in the de Lijser group is two-fold. We use physical organic techniques to study the reactive intermediates formed in the enzymatic and photooxidative processes of xenobiotic compounds used as drugs and pesticides (mostly those with oxime and oxime ether functionalities). The reactive intermediates are generated by thermal and photochemical techniques. Molecules of interest are synthesized, purified and characterized. The chemistry of the reactive intermediates is explored by laser flash photolysis and steady state photolysis experiments. Products are analyzed by gas chromatography, mass spectrometry and NMR techniques. We have shown that several different reactive intermediates are involved in the electron transfer reactions of oximes and oxime ethers. Current research interests are geared towards learning more about the specific reactivities of the different reactive intermediates, including iminoyl and iminoxyl radicals, in order to be able to exploit them in different processes.

In a collaborative project with Dr. Nilay Patel (Department of Biological Science, CSUF) we design and synthesize small organic molecules that can be used to maintain the pluripotency of stem cells. The goal of this collaboration is to design and synthesize drugs that can be used to block two proteins from interacting with one another and thereby promoting pluripotency in stem cells. The desired molecules are designed by molecular modeling and synthesized in the laboratory. A secondary goal is to perform a structure-reactivity study on a series of drugs in which only one small change occurs. We are currently focusing on several different classes of molecules (chalcones, amides, small peptides, carboxylic acids and esters), some of which have shown promising results in biological studies carried out by our collaborators in the Department of Biological Science at CSUF.