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Dr. Niroshika Keppetipola

Selected Publications

Keppetipola NM, Yeom KH, Hernandez AL, Bui T,* Sharma S, Black DL. *CSUF undergraduate "Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2." RNA.  2016 Aug; 22(8):  1172-80.

Keppetipola N, Sharma S, Li Q, and Black DL. (2012) “Neuronal regulation of Pre-mRNA Splicing by Polypyrimidine Tract Binding Proteins, PTBP1 and PTBP2” Crit Rev Biochem Mol Biol. 47(4):360-78. PMCID: PMC3422667

Keppetipola N, Jain R, Meineke B, Diver M, and Shuman S. (2009)“Structure-activity relationships in Kluyveromyces lactis gamma-toxin, a eukaryal tRNA anticodon nuclease.” RNA 15, 1036-44.  PMCID:  PMC2685522

Keppetipola N, and Shuman S. (2008) “A phosphate-binding histidine of binuclear metallophosphodiesterase enzymes is a determinant of 2',3' cyclic nucleotide phosphodiesterase activity” J. Biol. Chem. 283, 30942-9.  PMCID:  PMC2576524

Keppetipola N, and Shuman S. (2007) “Characterization of the 2’, 3’ cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase” Nucleic Acids Res. 35, 7721-32.  PMCID:  PMC2190708

Keppetipola N, Nandakumar J, and Shuman S. (2007) “Reprogramming the end healing pathway of a bacterial RNA repair enzyme.” Nucleic Acids. Res.35, 3624-3630.  PMCID:  PMC1920235

Keppetipola N, Jain R, and Shuman S.  (2007). "Novel triphosphate phosphohydrolase activity of Clostridium thermocellum TTM, a member of the triphosphate tunnel metalloenzyme superfamily" J. Biol. Chem. 282, 11941-9. PMID: 17303560

Keppetipola N, and Shuman S. (2006). "Distinct enzymic functional groups are required for the phosphomonoesterase and phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase."  J. Biol. Chem. 281, 19251-19259.  PMID:  16675457

Keppetipola N, and Shuman S. (2006).  "Mechanism of the phosphatase component of Clostridium thermocellum polynucleotide kinase-phosphatase." RNA 12, 73-82. PMCID:  PMC1370887

Keppetipola N, and Shuman S. (2005). "Characterization of a thermophilic ATP-dependent DNA ligase from the euryarchaeon Pyrococcus horikoshii." J. Bacteriol. 187, 6902-8. PMCID:  PMC1251619