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Dr. Madeline Rasche

Selected Publications

Chiem, K., Jani, S., Fuentes, B., Lin, D.A., Rasche, M.E., and Tolmasky, M.E.  2016.  Identification of an Inhibtor of the Aminoglycoside 6'-N-Acetyltransferase type lb [AAC(6')-lb] by Glide Molecular Docking.  MedChemComm 71:  184-189.

Bobik, T.A., Morales, E.J., Shin, A., Cascio, D., Sawaya, M.R., Arbing, M., Yeates, T.O. & Rasche, M.E. 2014. Structure of the methanofuran/methanopterin biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii. Acta Cryst. F70: 1472-1479.

McNamara, D.E., Cascio, D., Jorda, J., Bustos, C., Wang, T., Rasche, M.E., Yeates, T.O, and *Bobik, T.A. 2014. Structure of dihydromethanopterin reductase: a cubic Protein cage for redox transfer. J. Biol. Chem. 289:8852-8864.

Wang, S., Tiongson, J., and Rasche M.E. 2014. Discovery and characterization of the first archaeal dihydromethanopterin reductase (DmrX), an iron-sulfur flavoprotein from Methanosarcina mazei. J. Bacteriol. 196:204-209.

Testani, J., Dabelic, R. and Rasche, M. E. *.; 2006. Chemical reduction of pterins to dihydropterins.  Analytical Biochem. 358:20-24.

Rasche, M. E., and J. G. Ferry. 2005. Molecular Biology of Methanogens and Archaebacteria, p. 237-261. In R. A. Meyers (ed.), Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd ed, vol. 8. Wiley-VCH Verlag GmbH & Co., Weinheim. (Review)

Chistoserdova, L.*, Rasche, M.E., and Lidstrom, M.E.  2005.  Novel tetrahydromethanopterin biosynthesis genes discovered via mutagenesis in Methylobacterium extorquens AM1. J. Bacteriol. 187: 2508-2512.

Hamilton, R., Casasús, A., Rasche, M.E., Narang, A, Svoronos, S. A.*, and Koopman, B*. 2005.  A structured model for denitrifier diauxic growth.  Biotechnology and Bioengineering, 90(4):501–508.

Caccamo, M. A., Malone, C. S., and Rasche, M. E.*  2004.  Biochemical characterization of dihydromethanopterin reductase, a tetrahydromethanopterin biosynthesis enzyme in Methylobacterium extorquens AM1. J. Bacteriol.186:2068-2073.

Rasche, M. E.*, Wyles, S. A., and Rosenzvaig, M.  2004.  Characterization of two methanopterin biosynthesis mutants of Methylobacterium extorquens by use of a tetrahydromethanopterin bioassay.  J. Bacteriol. 186:1565-1570.

Bobik, T.A., Rasche, M.E.*  2004. Purification and partial characterization of the Pyrococcus horikoshii methylmalonyl-CoA epimerase.  Applied Microbiology and Biotechnology 63:682-685.

Rasche, M. E.*  2004.  Outcomes of a research-driven laboratory and literature course designed to enhance undergraduate contributions to original research.  Biochem. and Molecular Biology Educ. 32:101-107.

Kima, P.E.*, Rasche, M.E.  2004.  Sex determination using the polymerase chain reaction.  Biochem. and Molecular Biology Educ. 32:115-119.

Dumitru, R., Palencia., H., Schroeder, S. D., DeMontigny, B., Takacs, J., Rasche, M. E., Miner, J. L., and Ragsdale, S. W.*  2003.  Targeting methanopterin biosynthesis to inhibit methanogenesis.  Appl. Environ. Microbiol. 69:7236-7241.