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Dr. Nicholas T. Salzameda

Associate Professor Organic & Bioorganic Chemistry

Dr. Dr. Nicholas T. Salzameda

The synthesis of novel peptide catalysts for asymmetric carbon-carbon bond forming reactions. The discovery of biologically active molecules for disruption of protein-protein interactions, focusing on targets related to human health. Both of these research objectives are centered on solid phase reaction methodology.

 

Office: MH-582J
Phone: (657) 278-3594
Lab: DBH-182/183
Phone:(657) 278-3913/2596
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.


Courses Taught

  • CHEM 301A Organic Chemistry
  • CHEM 302 Organic Chemistry Laboratory

Education

Postdoctoral, The Scripps Research Institute, La Jolla, CA (Professor Kim Janda)

Ph.D. University of Nevada, Reno (Professor David Lightner)

B.A. University of San Diego, California


Research Interests

We are involved in two areas of research: the synthesis of novel peptide catalysts for asymmetric carbon-carbon bond forming reactions and the discovery of biologically active molecules for disruption of protein-protein interactions, focusing on targets related to human health. Both of these research objectives are centered on solid phase reaction methodology. 


Selected Publications

Lowery, C. A.; Salzameda, N. T.; Sawada, D.; Kaufmann, G. F.; Janda, K. D. “Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing” J. Med. Chem. Accepted (2010)

Eubanks L.M.; Silhar, P, Salzameda, N.T.; Zakhari J. S.; Xiaochuan F.; Barbieri, J. T.; Shoemaker, C. B.; Hixon, M. S.; Janda, K. D. “Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease” ACS Med. Chem. Lett. In press (2010)

Silhar, P.;Capkova, K.; Salzameda, N.T.; Barbieri, J.T.; Hixon M.S.; Janda, K.D. “Botulinum Neurotoxin Protease A: Discovery of Natural Product Exosite Inhibitor” J. Am. Chem. Soc. 2010132, 2868-2869.

Salzameda, N.T.; Barbieri, J.T.; Janda, K.D. “Synthetic Substrate for Application in both High and Low Throughput Assays for Botulinum Neurotoxin B Protease Inhibitors” Bioorg. Med. Chem. Lett.2009 19, 5848-5850.

Capkova, K.; Salzameda, N. T.; Janda, K. D., “Investigations into Small Molecule Non-peptidic Inhibitors of the Botulinum Neurotoxins” Toxicon200954, 575-582.

Salzameda, N. T.; Lightner, D. A., “Intramolecular hydrogen-bonding in C(10) homologated bilirubinoids” Monatsh. Chem., 2007138, 237-244.

Salzameda, N. T.; Huggins, M. T.; Lightner, D. A., “Novel N(23)-C(10)-linked linear tetrapyrroles” Tetrahedron, 2006,62, 9827-9831.