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Dr. Kelvin Billingsley

Selected Publications

Park, J. M.; Wu, M.; Datta, K.; Liu, S.-C.; Castillo, A.; Lough, H.; Spielman, D. M.; Billingsley, K.* Hyperpolarized Sodium [1-13C]-Glycerate as a Probe for Assessing Glycolysis In Vivo. J. Am. Chem. Soc. 2017, 139, 6629-6634.

Haynes-Smith, J.; Diaz, I.; Billingsley, K.* Modular Total Synthesis of Protein Kinase C Activator (–)-Indolactam V. Org. Lett. 2016, 18, 20082011.

Thomas, C.; Wu, M.; Billingsley, K.* An Amination-Oxidation Strategy for the Synthesis of Monoarylamines. J. Org. Chem. 2016, 81, 330-335.

Josan, S.; Billingsley, K.; Orduna, J.; Park, J. M.; Luong, R.; Yu, L.; Hurd, R.; Pfefferbaum, A.; Spielman, D.; Mayer, D. Assessing Inflammatory Liver Injury in an Acute CCl4 Model using Dynamic 3D Metabolic Imaging of Hyperpolarized [1-13C]-Pyruvate. NMR Biomed. 2015, 28, 1671-1677.

Loy, B. A.; Lesser, A. B.; Staveness, D.; Billingsley, K.; Cegelski, L.; Wender, P. A. Toward a Biorelevant Structure of Protein Kinase C Bound Allosteric Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogs for Analysis with Solid-State REDOR NMR Spectroscopy. J. Am. Chem. Soc. 2015, 137, 3678-3685.

Billingsley, K.;* Josan, S.; Park, J. M.; Tee, S. S.; Spielman-Sun, E.; Hurd, R.; Mayer, D.; Spielman, D. Hyperpolarized [1,4-13C]Diethylsuccinate: A Potential DNP Substrate for In Vivo Metabolic Imaging. NMR Biomed. 2014, 27, 356-362.

Billingsley, K.;* Park, J. M.; Josan, S.; Hurd, R.; Mayer, D.; Spielman-Sun, E.; Nishimura, D.; Brooks, J. D.; Spielman, D. The Feasibility of Assessing Branched-Chain Amino Acid Metabolism in Cellular Models of Prostate Cancer with Hyperpolarized [1-13C]-Ketoisocaproate. Magn. Reson. Imaging 2014, 32, 791-795.

Düfert, M. A.; Billingsley, K.; Buchwald, S. L. Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation. J. Am. Chem. Soc. 2013, 135, 12877-12885.

Wender, P. A.; Billingsley, K. Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues. Synthesis 2013, 45, 1815-1824.

Josan, S.; Hurd, R.; Billingsley, K.; Senadheera. L; Park, J.; Yen, Y.-F.; Pfefferbaum, A.; Spielman, D.; Mayer, D. Effects of Isoflurane Anesthesia on Hyperpolarized 13C Metabolic Measurements in Rat Brain. Magn. Reson. Med. 2013, 70, 1117-1124.

Balaconis, M. K.; Billingsley, K.; Dubach, M.; Cash, K. J.; Clark, H. A. The Design and Development of Fluorescent Nano-Optodes for In Vivo Glucose Monitoring. J. Diabetes Sci. Technol. 2011, 5, 1650-1657.

Billingsley, K.; Balaconis, M. K.; Dubach, J. M.; Zhang, N.; Lim, E.; Francis, K. P.; Clark, H. A. Fluorescent Nano-Optodes for Glucose Detection. Anal. Chem. 2010, 82, 3707-3013.

Billingsley, K.; Buchwald, S. L. A General and Efficient Method for the Suzuki-Miyaura Coupling of 2-Pyridyl Nucleophiles. Angew. Chem. Int. Ed. 2008, 47, 4695-4698.

Billingsley, K.; Buchwald, S. L. An Improved System for the Palladium-Catalyzed Borylation of Aryl Halides with Pinacol Borane. J. Org. Chem. 2008, 73, 5589-5591.

Billingsley, K.; Barder, T. E.; Buchwald, S. L. Palladium-Catalyzed Borylation of Aryl Chlorides: Scope, Applications, and Computational Studies. Angew. Chem. Int. Ed. 2007, 46, 5359-5363.

Billingsley, K.; Buchwald, S. L. Highly Efficient Monophosphine-Based Catalyst for the Palladium-Catalyzed Suzuki-Miyaura Reaction of Heteroaryl Halides and Heteroaryl Boronic Acids and Esters. J. Am. Chem. Soc. 2007, 129, 3358-3366.

Billingsley, K.; Anderson, K. W.; Buchwald, S. L. A Highly Active Catalyst for Suzuki-Miyaura Cross-Coupling Reactions of Heteroaryl Compounds. Angew. Chem. Int. Ed. 2006, 45, 3484-3488.

Brizius, G.; Billingsley, K.; Smith, M. D.; Bunz, U. H. F. Conformational and Electronic Engineering of Twisted Diphenylacetylenes. Org. Lett. 2003, 5, 3951-3954.